NIH R01 · 2024
Impact of TB coinfection on HIV reservoir
People living with HIV (PLHIV) are 18 times more likely to have an active TB infection than people without HIV. Though significant epidemiological evidence highlights the significantly worse outcomes for HIV and tuberculosis (TB) co-infections, the mechanisms underlying this increased risk have not been identified. This is particularly important since all-cause mortality is four times higher for people living with HIV (PLHIV) that also have a history of active TB compared to PLHIV without TB, regardless of TB cure and effective ART. This research team's preliminary data suggest differences in the HIV reservoir, the latent HIV virus integrated into host cell DNA throughout the body, as a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.