NIH R01 · 2025
MRI Study of Hydrogen Water and Minocycline Combination Therapy for Ischemic Stroke
ABSTRACT MRI has become a standard method to evaluate the extend of injury in the brain after stroke and possibly guide treatments. This proposal aims to: i) develop and implement novel multiparametric MRI methods to determine viability tissue status and to investigate therapeutic effects, ii) to apply these methods to evaluate the efficacy for hydrogen water, minocycline, and combination of hydrogen water and minocycline treatment in the established rat stroke model. Part one involves development of sophisticated multimodal MRI acquisition and analysis methods to longitudinally characterize and track tissue viability, cerebral functional status, and cerebral vascular reactivity, beyond…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.