NIH R01 · 2025
Synaptic and circuit mechanisms of compensation following loss of cone inputs in the mature retina
PROJECT SUMMARY/ABSTRACT More than 50% of cones can be lost before vision degrades, a discrepancy which can prevent earlier diagnosis of retinal diseases. A gap exists in understanding the relationships between the degrees of cone loss and impact on specific visual circuits and behavior. Rigorously establishing such links would benefit earlier diagnosis and treatment monitoring. Barriers to understanding these relationships and to the long-term goal of improving diagnosis and treatment of photoreceptor degenerations, include (1) simultaneous examination of a visual behavior and its underlying physiology in ganglion cells specialized for that visual behavior; and (2) identification of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.