Dunn Lab

Massachusetts General Hospital

Boston · United States

NIH-funded
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NIH R01 · 2024

Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of protective factors and sensitive periods in development

Project Summary. Exposure to childhood adversity is one of the strongest risk factors for depression across the life course, increasing risk by at least twofold. Although these exposures are clearly harmful, there is substantial variation in how people respond to adversity; not all children who experience early-life adversity go on to develop mental health problems. This finding raises the question: Are there modifiable factors early in life that protect against the effects of adversity, contribute to resilient biological processes, and prevent new onsets of depression? Family- and community-level factors, including maternal social support, parenting behaviors, grandparent involvement, peer…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.

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