NIH R01 · 2024
Regulation and mechanism of RND-mediated antibiotic efflux in Pseudomonas
ABSTRACT Bacterial resistance to antibiotics is an escalating crisis in healthcare that threatens to fundamentally alter modern medicine. Among several prevalent mechanisms of resistance, intrinsic multidrug efflux pumps of the Resistance-Nodulation-cell Division RND superfamily are broadly distributed among pathogenic bacteria (particularly Gram-negatives) and contribute extensively to clinical resistance. The important opportunistic pathogen Pseudomonas aeruginosa encodes multiple RND efflux systems, at least four of which contribute to its intrinsic multi-drug resistance. P. aeruginosa can cause both acute and chronic infections in susceptible individuals that are thus notoriously…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.