NIH R01 · 2024
Interrogating MRCK Protein Kinases in Ovarian Cancer
The majority of recurrent ovarian cancers spread to the peritoneal cavity in the form of ascites, where tumor cells grow as spheroids, and metastasize to other organs causing morbidity and death. The overall goal of this proposal is to define the mechanisms by which protein kinases control spheroid growth and metastasis of ovarian cancer cells, and use this information to develop kinase inhibitor therapies for the treatment of recurrent ovarian cancer. The Cdc42 downstream effector protein kinases MRCKα and MRCKβ (MRCKs) are highly expressed in ovarian cancer and have been implicated in cell migration, invasion and metastasis. Strikingly, we recently discovered that inhibition of MRCK…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.