Chapiro Lab

Yale University

RADIATION-DIAGNOSTIC/ONCOLOGY

New Haven · United States

NIH-funded
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NIH R01 · 2025

Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver Cancer

Project Summary Liver cancer is the fourth most common cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is on the rise in the western world. Minimally inva- sive, catheter-based locoregional therapies (LRT), such as transarterial chemoembolization (TACE), are now the mainstay treatments for intermediate to advanced stage HCC and are included in all management guidelines. TACE is a palliative therapy that prolongs survival by controlling intra-hepatic tumor progression via targeted is- chemic injury, paired with the delivery of highly concentrated chemotherapy into the tumor-feeding artery. More recently, systemic…

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