NIH R01 · 2024
Oocyte genomic instability as a driver of the aging ovarian innate immune response
PROJECT SUMMARY Overall tissue function deteriorates with age, but the female reproductive system is the first to age. Female reproductive aging is characterized by a decline in egg quantity and quality which contributes to miscarriages, infertility, and birth defects. Cessation of reproductive function at menopause also accelerates overall aging because the gonadal hormone, estrogen, regulates numerous tissues (e.g., brain, heart, bone, immune cells, reproductive tract). The consequences of female reproductive aging are significant because women are delaying childbearing, and medical interventions have increased the gap between menopause and lifespan. Thus there is a critical need to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.