NIH R01 · 2024
Development of Two Novel AMD Models for Evaluation of RPE Protection by the Novel Antioxidant D-DHA
PROJECT SUMMARY Geographic atrophy (GA) is the advanced form of dry age-related macular degeneration. Recently, anti-complement drugs have shown moderate efficacy in slowing disease progression. The long-term goals of the proposed studies are to develop two new mouse models of GA based on RPE oxidative stress for testing potential novel therapeutics. We will test one such therapeutic, oral deuterated docosahexanoic acid (D-DHA), which has shown considerable promise in an acute model of photoreceptor oxidative stress caused by intravitreal iron injection. Oxidation of DHA has been implicated in AMD pathogenesis by Joe Hollyfield's lab. Now it is important to determine whether this…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.