NIH R01 · 2025
Contribution of Glia to Sleep/Wake Disturbances in FXS
Sleep impairments are commonly reported in Fragile X syndrome (FXS) and autism spectrum disorders (ASD). Sleep impairments can have profound negative impact on brain development, cognition and general well-being however the underlying brain defects of sleep impairments in FXS are not well understood. While most research of sleep mechanisms have focused on neurons, recent studies revealed a critical role of astrocytes, a type of glia in the brain, as regulators of sleep and wake. Specifically, astrocyte Ca2+ signals exhibit distinct features across the sleep-wake cycle, are reduced during sleep compared to wakefulness and manipulating astrocyte Ca2+ signaling impacts sleep. Astrocytes in FXS…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.