NIH R01 · 2024
Sex-Specific Genetic Drivers of Alzheimer's Disease Endophenotypes
Abstract As the population ages, late-onset Alzheimer’s disease (AD) is becoming an increasingly important public health issue. AD disproportionately affects women. Of the more than 5 million people in the United States afflicted with this disease, two-thirds are women. Women with AD have more neuropathology than men with AD, have more severe cognitive symptoms, and more severe neurodegeneration, suggesting that the disease affects male and female brains in different ways. Thus, a focus on sex differences in AD is essential to move the field towards effective interventions. The identification of sex-specific genetic drivers of AD and AD-related endophenotypes could transform the way…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.