NIH R01 · 2025
Molecular and cellular mechanisms of neuronal damage caused by anticancer therapies
Project Summary Cancer is a terrifying diagnosis, especially in a child, yet thanks to great advances in treatment, survival rates have increased steeply. For CNS/brain tumors and leukemias, which together account for the majority of pedi- atric cancers, these positive clinical outcomes generally require the use of CNS radiotherapy (RT). However, RT causes significant long-term neurocognitive sequelae impacting not only cancer survivors, but also their caregi- ver networks and society. Since RT is a scheduled ‘injury’, pretreatment is feasible, but the unclear nature of RT- induced cognitive injury is a major obstacle to doing so. Research addressing RT-mediated cognitive deficits has…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.