NIH R01 · 2025
Selenium Supplementation for Moderate-Severe Ulcerative Colitis Flares
Selenium deficiency is common in ulcerative colitis (UC), even during periods of quiescent disease, and deficiency of selenium in UC is associated with an increased risk for disease flares and need for colectomy. Recent evidence demonstrates that coloncytes can directly uptake selenium and use it to synthesize selenoprotein-P (SELENOP), which is secreted basolaterally into the colonic microenvironment. Myeloid specific loss of SELENOP, but not epithelial specific loss of SELENOP, results in increased susceptibility to induction of colitis. Through large integrated human single-cell and spatial transcriptomics datasets, we observed an inverse association between myeloid SELENOP expression…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.