NIH R01 · 2024
Trans-ancestry, single-cell multiomics dissection of IBD-associated loci in CD4 memory T cells
PROJECT SUMMARY/ABSTRACT Crohn’s disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), affect ~3.7 million Americans and Europeans, and several hundred thousand more worldwide. Genome-wide association studies have identified more than 200 IBD loci, but distinguishing causal genetic variants from non-causal variants in linkage disequilibrium, and understanding how non-coding, presumably regulatory variants with the strongest association signals in most IBD loci confer risk are challenges for functional and clinical translation. Multiomic data integration and epigenetic fine mapping in IBD-relevant cell types and contexts can bridge knowledge gaps between…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.