NIH R01 · 2024
Mechanisms of de novo cardiac sarcomere assembly
PROJECT SUMMARY The ability of the heart to contract continuously is vital to the organism and is dictated in part by the sarcomeres, the functional units of the contractile apparatus. Consequently, any errors in the formation, composition or homeostasis of the sarcomere structure lead to congenital heart defects (CHD) or various forms of cardiomyopathy. While the highly complex structure of the cardiac sarcomere and its function have been studied extensively for decades, comparatively little remains known about how the sarcomere structure is established in the first place, during de novo sarcomerogenesis. Current knowledge is largely qualitative as in depth mechanistic studies are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.