NIH R01 · 2024
Understanding the mechanism of genetic transformation
Natural transformation in bacteria is an important mode of horizontal gene transfer that contributes to bacterial evolution, including the spread of antibiotic resistance and virulence genes. This proposal will use Bacillus subtilis as a model to address the largely conserved mechanisms that enable the uptake of environmental DNA. It will address the traversal of transforming DNA through the cell wall, the translocation of DNA across the cell membrane, and steps during the recombination of this DNA with the recipient genome. Our studies will provide broad insights into molecular details of transformation and will bring us closer to the long-term goal of understanding the mechanism of DNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.