NIH R01 · 2024
Elucidating the Biology of Cardiovascular Risk in Hemodialysis Patients Using Proteomics
PROJECT SUMMARY The 500,000 patients in the United States with end-stage renal disease (ESRD) on hemodialysis (HD) suffer extraordinarily high rates of mortality at ~18% per year, with 50% of these deaths attributed to cardiovascular disease (CVD): namely, atherosclerotic CVD, heart failure, and sudden cardiac death. Effective approaches for prevention, treatment and risk stratification in the HD population are lacking. Medical therapies that are effective in patients without ESRD, such as statins, are not beneficial for patients with ESRD when tested in randomized clinical trials. Ironically, traditional CVD risk factors, such as hypercholesterolemia, obesity, and hypertension, have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.