NIH R01 · 2024
Mechanisms of X-Chromosome-dependent Sex Difference inAlzheimers Disease
PROJECT SUMMARY/ABSTRACT Biologic sex influences Alzheimer's disease (AD) and whether sex chromosomes play a role is unknown. This grant focuses on X-chromosome-derived mechanisms of sex difference that contribute to AD by integrating mouse model and human studies. Understanding this largely unstudied area may reveal new X-based pathways that could ultimately benefit both sexes. Sex differences in AD reveal differing vulnerabilities in men and women. In brief, male sex is a risk factor for rapid progression to death in AD and other neurodegenerative conditions. These findings support the fact that many more women have AD, due in part to their longevity and also to their increased risk or…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.