Duan Lab

University of California, San Francisco

OPHTHALMOLOGY

San Francisco · United States

NIH-funded
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NIH R01 · 2025

MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS

PROJECT SUMMARY The precise assembly of neural circuits ensures accurate neurological function and behavior. For example, to communicate specific aspects of the visual world to the brain, retinal ganglion cells (RGCs) find and form synaptic contacts with specific postsynaptic partners out of the heterogeneous neuronal population of retino-recipient areas in the brain. One such area is the superior colliculus (SC), which receives direct retinal inputs and sends commands for direct innate behaviors such as escape or prey capture. What are the molecular determinants for selective RGC to SC neuron wiring? How are parallel retinotectal circuits sorted onto different SC laminae and neuronal…

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