NIH R01 · 2025
The term "prion" was originally coined to describe the agent responsible for neurodegenerative diseases associated with the prion protein, PrP. This concept has now broadened to encompass a wide range of proteins in various organisms, linked to crucial cellular functions or diseases. For example, human pathogenic proteins like Aβ, tau, α-synuclein and p53 in cancer and neurodegeneration have been proposed to follow prion-like mechanisms. However, the precise role of prions in these proteinopathies remains unclear. Yeast is a valuable platform for prion research, with several prion proteins acting as transcription modulators. One notable example is [SWI+], the prion form of Swi1, a component…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.