NIH R01 · 2025
In Vivo 3-D Multi-Isotope Autoradiography of Radiopharmaceutical Therapy
Abstract: Radiopharmaceutical therapy (RPT) is a highly effective cancer treatment, especially for metastatic cancers. There is significant interest in developing novel radiopharmaceuticals labeled with β-emitters (βRPT) or α-emitters (αRPT) for various cancer types. Due to the limited range of α-particles and the low energy of β-particles, it is crucial to measure the distribution of these radiopharmaceuticals at a microscale level within the organs and tumor anatomy of small animals, commonly used for studying RPT toxicity and efficacy. For example, while the full liver and kidneys may serve as sources and targets in the regular dosimetry schema for intermediate-to-high energy βRPT, more…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.