NIH R01 · 2024
Mechanisms of Trabecular Meshwork Regeneration by Stem Cells
Project Summary Glaucoma is a leading cause of irreversible blindness throughout the world and the second leading cause of blindness overall in the USA. Elevated intraocular pressure (IOP) and aging are the most important risk factors for most forms of glaucoma. IOP level is highly dependent on the rate at which the aqueous humor is filtered through the conventional outflow pathway containing the trabecular meshwork (TM). Reduced cellularity within the TM and abnormal extracellular matrix (ECM) turnover occur in glaucomatous conditions and correlate with increased outflow resistance, elevated IOP, and subsequent vision loss. The goal of this project is to define the mechanisms of stem cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.