NIH R01 · 2025
Role of LAM-specific TREM1 in leukemogenesis
PROJECT SUMMARY/ABSTRACT Cancer progression is heavily influenced by supportive cells in the tumor microenvironment. Macrophages, an important component of tissue microenvironment, play important roles in both physiological and pathological processes. Macrophages that infiltrate into tumor tissues are regarded as tumor-associated macrophages (TAMs) or leukemia-associate macrophages (LAMs) in leukemia. Although a connection between LAMs and hematologic malignancies has long been appreciated, the molecular mechanism by which LAMs promote leukemogenesis is far less understood. We have employed Fanconi anemia (FA), a genetic disorder associated with bone marrow failure and progression to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.