NIH R01 · 2024
Maximizing sensitivity for ultra-low dose PET imaging
Summary Small-animal positron emission tomography (PET) has been widely used as a powerful tool for preclinical studies to image a wide range of biological processes in vivo. The key parameters in PET are its spatial resolution and sensitivity that determine the ability to image and quantify radiotracers in a small region of the subject at sub- nanomolar concentrations. However, the applications of small-animal PET have been limited in its application by a combination of spatial resolution and more importantly, the sensitivity, which hampers the use of PET for a range of applications including imaging of low-levels of receptor and transgene expression, imaging of therapeutic cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.