NIH R01 · 2025
mtDNA leakage and STING-dependent microglial innate immune response in Alzheimer's disease
PROJECT SUMMARY Characterized by progressive cognitive decline, Alzheimer's disease (AD) is the most common type of dementia, primarily affecting the aging population. Inflammatory activation of microglia is an early pathological feature of Alzheimer’s disease (AD) and contributes to brain damages. However, the underlying mechanisms that mediate microglial inflammatory activation in Aβ-rich milieus are not completely understood. Stimulator of interferon genes (STING) is an innate immune adaptor protein that is abundantly expressed by cells of myeloid origin including microglia. Despite its roles in interferon-based antiviral immunity, recent studies have revealed an important contribution…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.