NIH R01 · 2024
Guanidinium Toxins as Molecular Probes for NaV Study
PROJECT SUMMARY Neuronal excitability relies on the tightly regulated expression and discrete subcellular localization of voltage-gated sodium ion channels (NaVs). These large membrane protein complexes control the movement of sodium ions across cell membranes and are responsible for initiating and propagating action potentials. A desire to better understand the role of NaV subtypes in electrical signal conduction and the relationship between channel dysregulation and specific human pathologies (e.g., arrhythmia, epilepsy, skeletal muscle disorders, neuropathic pain) motivates the development of high precision reagents to facilitate NaV studies. Investigations of NaV physiology are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.