NIH R01 · 2024
HIV-Associated Lung Disease: The Role of Nasal Mucosal Immunity and Microbiome
PROJECT SUMMARY/ABSTRACT People living with HIV (PLWH) are at heightened risk for chronic lung diseases. The mechanisms underlying this risk are poorly understood. Viral infections are major causes of acute respiratory events including pneumonia as well as asthma and COPD exacerbations, all of which can increase the risk of chronic lung impairments. The nasal mucosal “secretome”, composed of cytokines/chemokines and other soluble mediators, limits the initial spread of viral infections through controlling viral entry, releasing cytokines/chemokines, as well as numerous immune modulating mediators. The nasal microbiome, including bacterial microbiome and fungal mycobiome, is a critical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.