Drummond Lab

Research focus

NIH R01 · 2024

Leveraging senotherapeutic properties of metformin to improve collagen remodeling during muscle regrowth in older adults

Abstract A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence. Mechanistic-based therapeutic strategies to enhance muscle recovery in older adults do not exist. Synchronized muscle interstitial cellular events involving immune cells (e.g., macrophages), fibro-adipogenic progenitor (FAP) cells and satellite cells are critical to promote myogenesis, extracellular matrix (ECM) remodeling, and ultimately, restore muscle size and function. However, in aging, senescence cells exceed the rate of removal during recovery from injury…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.