NIH R01 · 2024
ABSTRACT Mechanosensing is a process inherent to nearly all cell types, including vascular smooth muscle (VSM) cells where pressure-induced vascular stretch initiates a mechano-dependent vasoconstriction. This response, termed pressure-induced constriction, occurs in numerous organs including the kidney and serves at least two functions: control of local blood flow and prevention of transmission of damaging high systemic pressures to delicate microvessels. A loss of the pressure-induced constriction response increases susceptibility to vascular injury in organs, including the kidney where a loss of this response accelerates progression of chronic kidney disease. Despite the importance of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.