NIH R01 · 2025
Role of GLUT1 in diabetic cardiomyopathy
ABSTRACT Diabetic cardiomyopathy (DbCM), which occurs in either Type-1 Diabetes (T1D) or Type-2 Diabetes (T2D), defines heart failure (HF) that occurs in the absence of coronary artery disease, hypertension, and valvular disease. Our research has discovered in human myocardial samples and mouse diabetic hearts and cardiomyocytes (CM) that the transcriptional factor Krüppel-like factor 5 (KLF5) is a central component of DbCM. We have also revealed mechanisms of KLF5-dependent cardiotoxicity that involve oxidative stress and lipotoxicity, which combinedly lead to DbCM. Furthermore, we showed that KLF5 upregulation in diabetes is driven by the transcriptional factor FOXO1. New data identify…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.