NIH R01 · 2024
Inflammatory Cytokine Networks in Gastrointestinal Tract Graft Versus Host Disease
Graft versus host disease (GVHD) is the major complication associated with allogeneic hematopoietic stem cell transplantation (HSCT). During the acute phase of this disease, a restricted set of organs is affected of which the gastrointestinal (GI) tract is the most clinically significant. Proinflammatory cytokines play a critical role in the pathophysiology of intestinal GVHD, in part, by activating donor innate and T cell populations which subsequently induce tissue damage. We previously demonstrated that CD4+ T cell production of granulocyte- macrophage colony stimulating factor (GM-CSF) plays a critical inflammatory role in the pathophysiology of GI GVHD. More recently, we have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.