NIH R01 · 2025
Molecular and Cell Biological Foundations of Proteostress-Induced Neuronal Extrusion
Healthy aging of the brain is highly dependent upon a range of protein quality control systems, and such quality control capacity is often disrupted in neurodegenerative disease. Recently it has come to light that diseased neurons can transfer toxic products, such as aggregated proteins, to neighboring cells, likely leading to the spread of pathology within the brain. How neurons generate and send out extracellular material in vivo is a question that must be addressed as we consider therapeutic intervention. Basic research can inform on mechanisms relevant to late onset neurodegenerative disease and can suggest avenues of treatment. Our studies take advantage of the enormous technical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.