NIH R01 · 2025
Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI
Project Summary/Abstract Dyspnea (shortness of breath) is among the most common reasons for seeking medical attention. It has a prevalence rivaling chronic pain and accounts for 10% of emergency room visits. Dyspnea workups involve extensive diagnostic testing, with high cost, and a slow time to diagnosis. The burden of dyspnea will further increase as more patients present with symptoms from long COVID. 129Xe MRI provides a promising solution with its comprehensive, non-invasive, and rapid imaging of lung function. Enabled by its solubility and tissue- dependent chemical shift, 129Xe probes diffusive transfer from the distal airspaces through the pulmonary interstitium (membrane) to the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.