NIH R01 · 2024
Pax2 Interacting Proteins in Development and Disease
ABSTRACT This competitive renewal application investigates how critical genes and pathways that determine renal epithelial cell differentiation, growth, and survival contribute to normal renal physiology and recovery from acute kidney injury. During previous funding periods, we have made significant breakthroughs in defining the mechanisms of Pax2 protein function in development and disease. Interactions between Pax proteins and epigenetic writers can imprint epithelial specific fates during development. In adults, the related gene Pax8 is expressed in all epithelial cells, whereas Pax2 is restricted to collecting ducts in the inner and outer medulla. How these two proteins function…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.