NIH R01 · 2025
Re-entry Supplement associated with R01AG08073
PROJECT SUMMARY During early stages of Alzheimer’s Disease (AD), skeletal muscle mass and function precipitously declines in comparison to those who are cognitively intact, potentially due to poor neuromuscular health. Thus, bioenergetics of peripheral tissues may have an underappreciated role in AD etiology. Exercise is an effective means to promote mitochondrial and neuromuscular health. However, whether regular exercise has therapeutic potential for delaying or preventing AD is an outstanding question. Thus far, we have shown in 5xFAD mice, a model of AD, neuromuscular dysfunction is present at a young age before observable cognitive decline and that muscle mitochondrial respiration does…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.