Doyle Lab

State University of New York at Buffalo

PATHOLOGY

Amherst · United States

NIH-funded
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NIH R01 · 2024

A Quantitative Risk Model for Predicting Outcome and Identifying Structural Biomarkers of Treatment Targets in Oral Cancer on a Large Multi-Center Patient Cohort

Post-resection prognostication for oral cavity cancers (OCC) is qualitative and potentially ambiguous. A significant subset (25-37%) of Stage I/II patients still develop local recurrence after treatment with surgery alone. The long-term goal of this proposal will be to create a Quantitative Risk Model (QRM) using machine learning and artificial intelligence to predict recurrence risk for Stage I/II patients using image-based biomarkers of aggression. The objective is to develop and validate state-of-the-art systems for biomarker imaging, quantification, and modeling to accurately predict risk of recurrence in cancer patients based on image analytics. The central hypothesis is that a…

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