NIH R01 · 2025
Causality of Post-TB Lung Disease: Population-Level Evidence from Rural Uganda
PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) is the leading single-agent cause of infectious mortality worldwide, including among people with HIV (PWH). TB survivors also continue to experience sequelae including post-TB lung disease (PTLD) and higher mortality. It remains uncertain, however, how much of these post-TB sequelae reflect TB itself versus underlying pre-TB risk factors and lung disease. For example, if a substantial burden of PTLD reflects pre-existing lung damage due to smoking – itself a risk factor for TB – then preventing TB may have minimal effect on this burden, and we should prioritize efforts to augment smoking cessation (including among people at risk for TB). By…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.