NIH R01 · 2025
Global post-transcriptional regulators in P. aeruginosa
Abstract Pseudomonas aeruginosa is an important opportunistic pathogen of humans. It is the principal cause of morbidity and mortality in persons with cystic fibrosis (pwCF), is a major cause of hospital-acquired pneumonia and is particulary problematic in burn wound infections. Hfq is a conserved global post-transcriptional regulator that is required for the virulence of P. aeruginosa. In other organisms Hfq is best known for its ability to promote the base-pairing between small regulatory RNAs (sRNAs) and their target transcripts, with Hfq-promoted interaction between an sRNA and its mRNA target typically functioning to repress target translation. Although approximately 150 different…
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