NIH R01 · 2024
Multimodal regulation of intracellular lipid surveillance
Project Summary/Abstract Lipid signaling is crucial for regulating organismal physiology and metabolic expenditure, and disturbances in lipid homeostasis can deleteriously impact health. Cells tightly control the absorption, synthesis, and breakdown of lipids to accommodate energetic demands and ensure energetic reserves later in life. We recently reported a mechanism by which cells sense metabolic demand resulting from lipid depletion and respond by increasing expression of genes involved in membrane trafficking as well as nutrient absorption and catabolism. This is accomplished by the release of the starvation-responsive nuclear hormone receptor, NHR-49, from endocytic vesicles and its…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.