NIH R01 · 2024
Anatomic, Physiologic and Transcriptomic Mechanisms of Neuropathic Pain in Human DRG
We have launched a collaborative effort between MD Anderson Cancer Center and University of Texas at Dallas that uses dorsal root ganglion (DRG) removed from pain phenotyped patients during neurological surgery. DRGs are taken from thoracic levels during a spine stabilization surgery and then cut in thirds. One third is saved for immunohistochemistry (IHC) or in situ hybridization (ISH), one third goes for culturing and electrophysiology, and one third is used for RNA sequencing. We have developed an extensive dataset with patient pain phenotype information, DRG neuron electrophysiological characterization and RNA sequencing. In many cases we have pairs of DRGs from the same patient where…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.