NIH R01 · 2025
ABSTRACT Severe spinal cord injury (SCI) often spares spinal circuitries innervating the hindlimbs but results in the loss of motor control below the injury due to compromised descending innervation of the cord. Plasticity after injury leads to the development of hyperreflexia and spasticity over time. Although hyperreflexia can be beneficial initially, facilitating motor output and locomotor function, it disrupts functional gains in the longer-term. The sensory afferents and their transmission within the cord are thought to be a primary mechanistic contributor to both regained locomotor function and hyperreflexia following SCI. Thus, identification of the mechanistic balance point between…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.