Doucette Lab

Dartmouth-Hitchcock Clinic

Lebanon · United States

NIH-funded
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NIH R01 · 2024

Evaluating the potential of neural oscillation biomarkers in a rodent model of intervention outcome variation: Toward personalized mental health care

PROJECT SUMMARY/ABSTRACT A major challenge in mental health care includes inconsistent outcomes of current psychotherapeutic, pharmacologic, and brain stimulation interventions. We theorize that across individuals, heterogeneous neural underpinnings manifest at a systems level, leading to impaired domains of function and specific diagnoses. This heterogeneity causes the same intervention to produce different outcomes across individuals. To overcome this challenge, we hypothesize that systems-level brain activity (neural oscillations) contains the information necessary to predict both individual variation in a domain of brain function and identify biomarkers to guide the individualized…

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