NIH R01 · 2025
Nucleus-to-cytoplasm trafficking of chromatin fragments in senescence and aging
PROJECT SUMMARY Cellular senescence is a stable form of cell cycle arrest program associated with pro-inflammatory responses. Senescent cells accumulate in diseased and aged tissues, where they impair tissue renewal and promote inflammation. Clearance of senescent cells using genetic or pharmacological tools ameliorates disease severity and promotes healthy aging. Therefore, understanding the biology of senescence is an important biomedical objective. The inflammatory program of senescence is a major contributor to the detrimental roles of senescence in aging and disease. Senescent cells secrete a large array of inflammatory cytokines, chemokines, proteases, and growth factors, collectively…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.