NIH R01 · 2024
Structural insights into the MLL core complexes
Project Summary Cancer epigenetics is an emerging field of high significance. It has led to the identification of novel therapeutic targets and biomarkers. Among chromatin remodeling complexes, driver mutations of the MLL family histone methyltransferases are commonly found in cancer. They lead to epigenetic aberrations that underlie cancer initiation, evolution, and metastasis. Understanding how the activity of the MLL family enzymes on chromatin is regulated and how its dysregulation leads to malignancy will shed light on disease mechanisms. We previously reconstituted a functionally active MLL1 core complex in vitro and identified four MLL1 core complex components, i.e. ASH2L, RbBP5,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.