NIH R01 · 2025
Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1
PROJECT SUMMARY/ABSTRACT Secreted and membrane proteins are important for cell survival and crosstalk. The rough endoplasmic reticulum (ER) is a dynamic organelle that adjusts to changes in protein folding demand by regulating secretory protein throughput. While recent studies examined transcriptional regulation of genes encoding secretory proteins in the heart, post-transcriptional regulation of protein expression remains largely unstudied. Here, post-transcriptional regulation genes encoding secretory proteins will be studied, which we found to be an important layer of gene expression control. ER-associated RNA-binding proteins that bind targeting elements in transcripts may orchestrate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.