Doris Lab

University of Texas Hlth Sci Ctr Houston

INTERNAL MEDICINE/MEDICINE

Houston · United States

NIH-funded
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NIH R01 · 2025

Long-read assembly and annotation of rat genomes that are important models of complex genetic disease

Project Summary: The rat is commonly used as an experimental model to investigate a wide diversity of biological processes of medical relevance. These include neuroscience and brain function, behavioral research, and drug dependency and addiction. Similarly, aspects of cardiovascular and renal function are more readily investigated in the rat where the volumes of fluid within these systems are on a much more manageable scale than in smaller rodents. The utility of rat models for investigation has led to the development of inbred rat strains that harbor medically relevant phenotypes. Such models have drawn on pre-existing, natural genetic variation to fix genomic diversity that creates…

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