NIH R01 · 2025
Physical model of the bacteria nucleoid
Project Summary The bacterial genome is organized into a compact form, known as the nucleoid, consisting primarily of the supercoiled circular DNA chromosome and DNA-binding proteins. Generation and maintenance of the nucleoid structure, which arises without a nuclear membrane or the chromatin present in eukaryotes, is critical to bacterial health; understanding the factors that give rise to this structure are thus important for promoting synergistic bacteria and disrupting antagonistic pathogens. Likewise, the dynamics governing DNA loci diffusion and intranucleoid transport govern the time scales for DNA-protein binding. A key open question surrounding the structure and dynamics of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.