NIH R01 · 2024
Critical Mediators of Inflammation Resolution and Immune Memory in Atherosclerosis
PROJECT SUMMARY Despite major medical advances, cardiovascular disease remains the major cause of morbidity and mortality worldwide. Even with aggressive risk factor control, nearly 50% of patients suffer recurrent cardiac events and this “residual risk” has been attributed to excessive inflammation. Recent work has demonstrated that atherosclerosis is also characterized by the failure of inflammation resolution. The resolution program is regulated by the production of specialized pro-resolving lipid mediators (SPMs) and the efficient clearance of apoptotic cells (efferocytosis) from tissue. Advanced atherosclerotic plaques have higher numbers of apoptotic cells, larger necrotic cores, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.