Donowitz Lab

University of Virginia

PEDIATRICS

Charlottesville · United States

NIH-funded
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NIH R01 · 2025

A Phase II Trial to Prevent Linear Growth Stunting and Malnutrition in Impoverished Children from a Low-Income Country by Treating Small Intestine Bacterial Overgrowth

PROJECT SUMMARY/ABSTRACT Stunting affects 23.8% of children under age 5 and is associated with poor neurodevelopment and early death. Small intestine bacterial overgrowth (SIBO) in impoverished children living in unsanitary environments in low-income countries is associated with intestinal inflammation and stunting. This project will build upon our preliminary data showing that SIBO predicts future stunting. Our objectives are to determine if treating SIBO in Bangladeshi infants under ideal conditions (i.e. frequent screening and treatment of all episodes) improves growth and to determine the structure and function of the enteric dysbiosis that children with SIBO have. Further, we will…

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