Donovan Lab

University of Illinois at Urbana-Champaign

NUTRITION

Champaign · United States

NIH-funded
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Research focus

NIH R01 · 2024

Elucidating Gene-Environment-Behavior Interactions to Uncover Causal Mechanisms for Obesity in Early Life

Trajectories leading to childhood obesity result from multifactorial Gene x Environment x Behavior interactions during a period of high developmental plasticity. Defining the causal mechanisms that mediate risk for obesity development in early life and how risk can be modified by psychosocial, contextual, and/or environmental factors, requires systems biology integration, which is currently lacking. The objective of this application is to develop predictive algorithms for childhood obesity risk by integrating data on growth trajectories, body composition, and dietary intake with multi omic (genetic, epigenetic and microbiome) data sets and assessments of temperament-self-regulation and…

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